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    Self-destructing genes herald new advances in gene therapy

    Bioengineers at The University of Texas at Dallas have created a novel gene-delivery system that shuttles a gene into a cell, but only for a temporary stay, providing a potential new gene-therapy strategy for treating disease. The vector – a delivery mechanism that carries genes into cells – for the new technique was created by using synthetic biology to combine DNA from a number of sources. It contains genes from a virus, certain bacteria, a sea anemone and a cow. The self-destruct mechanism comes from the bacterial genes produced protein Cas9, which can cause the introduced genes to break apart once their job is done.
    With our advanced next generation Gene Synthesis technology, General Biosystems provide custom DNA constructs that are 100% sequence-verified, giving you the ultimate flexibility to engineer vectors for novel gene therapy approaches.